Description:RecombinantmonoclonalantibodytoIL-2R.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthetherapeuticantibodyDaclizumab.
ThischimericcynomolgusmonkeyantibodywasmadeusingthevariabledomainsequencesoftheoriginalHumanIgG1format,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:CynomolgusmonkeyIgG1,kappa
CloneNumber:Daclizumab
UniProtAccessionNumberofTargetProtein:P01589
PublishedApplication(s):FC;Block
PublishedSpeciesReactivity:Human;RhesusMonkey;CynomolgusMonkey
Immunogen:CulturedT-cellsderivedfromapatientwithMycosisfungoides.
Specificity:Bindstop55chainofIL2RonhumanTcells,Tacantigen,whichisexpressedonTcellsactivatedbymitogens,solubleantigens,andalloantigensbutnotonrestingTcells,thymocytes,Bcells,monocytes,activatedBcells,leukemicTcellblastsfrompatientswithacutelymphoblasticleukemia,andlong-termTcelllines.
AntibodyFirstPublishedin:QueenC,SchneiderWP,SelickHE,PaynePW,LandolfiNF,DuncanJF,AvdalovicNM,LevittM,JunghansR,WaldmannTA.Ahumanizedantibodythatbindstotheinterleukin2receptor.ProcNatlAcadSciUSA.1989Dec;86(24):10029-33.PMID:2513570
Noteonpublication:DescribesthepreparationthehumanisedmouseantihumanTacmonoclonalantibodybycombiningtheCDRsofthemouseanti-Tacantibodywithhumanframeworkandconstantregionsandaffinitycharacterisation.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSonly.
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.