absoluteantibody/Ab00834-15.0 Anti-E-protein trimer (DENV3) [5J7]/Ab00834-15.0/50 µg,Absolute Antibody,,Absolute Antibody,absoluteantibody,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：absoluteantibody/Ab00834-15.0 Anti-E-protein trimer (DENV3) [5J7]/Ab00834-15.0/50 µg

产品编号：Ab00834-15.0

市场价：¥8512.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$425.60

品牌： Absolute Antibody

公司：Absolute Antibody

公司分类：

商品介绍

Description:RecombinantmonoclonalantibodytoE-proteintrimer(DENV3).ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromtheB-cellclone5J7.

ThisreformattedhumanantibodywasmadeusingthevariabledomainsequencesoftheoriginalHumanIgGformat,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.

SpeciesandIsotype:HumanIgM,kappa
CloneNumber:5J7
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):ELISA;FC;NTRL;cryo-EM
PublishedSpeciesReactivity:DengueVirus(allsubtypes)
Immunogen:Theoriginalhybridomawasgeneratedbyfusinganti-Dengueantibodyproducing,EBVimmortalisedB-cellsfromaDENV-immunepatient,withHMMA2.5myelomacells.
Specificity:ThisantibodybindstoDenguevirus3envelopeprotein.AsinglemutationintheDI-DIIhinge(lysineinsertionbetweenQ269andN270)abolishesbinding.Fibriansahetal(2015,PMID:25698059)reportthata5J7Fabbindsacrossthreeenvelopeproteinsandengagesthreefunctionallyimportantdomains,eachonadifferentprotein.
ApplicationNotes:ThisantibodybindstoDENV3E-proteinbyELISAandflow-cytometry.IthasalsobeenshowntoneutralizeDENV3virus,butnotDENV1,DENV2orDENV4.
AntibodyFirstPublishedin:
deAlwisetal.Identificationofhumanneutralizingantibodiesthatbindtocomplexepitopesondenguevirions.ProcNatlAcadSciUSA.2012May8;109(19):7439-44Noteonpublication:Describesthegenerationandcharacterisationofthisantibody.

ProductForm

Purification:AffinityPurifiedusingarecombinantlectincolumn
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.

Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.

品牌介绍

Absolute Antibody于2012年在英国剑桥成立，是由英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司，可以在两周内提供100mg级的工程化抗体，并且不含动物成分，批间差极小，消除因补体和Fc受体造成的背景，使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。目前提供国内的产品主要包括：

l 科研用生物仿制药抗体

l 嵌合单克隆抗体

l 用于体内实验的重组抗体

l 表位标签

l 重组非IgG同型对照

l 重组蛋白（Fc融合蛋白）

公司介绍

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