Description:RecombinantmonoclonalantibodytoDerp7.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaWH9.
ThischimerichumanantibodywasmadeusingthevariabledomainsequencesoftheoriginalMouseIgG2bformat,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:HumanIgG4-P,kappa
CloneNumber:WH9
UniProtAccessionNumberofTargetProtein:P49273
PublishedApplication(s):Block;
ELISAPublishedSpeciesReactivity:Housedustmite
Immunogen:RecombinantDerp7.
Specificity:ThisantibodybindstothehousedustmiteallergenDerp7andcompeteswithasubsetofnaturallyoccurringIgE.
ApplicationNotes:TheantibodybindsspecificallytoDerp7,ahousedustmiteallergenwhichplaysanimportantroleininflammatoryandhypersensitivereactions.TheantibodyWH9bindstoanepitopewhichisoverlappingwiththatofIgE,therebyinhibitingitsbindingbyupto60%.Bypreventingmastcelldegranulation,theantibodycanbeusefulinthedevelopmentofhypoallergenicvaccines.
AntibodyFirstPublishedin:Shenetal.CharacterizationofthehousedustmiteallergenDerp7bymonoclonalantibodies.ClinExpAllergy.1995May;25(5):416-22.
Noteonpublication:DescribestheroleofthehousedustmiteallergenDerp7inallergy,andthegenerationofmonoclonalantibodiesthattargetDerp7.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.