Description:RecombinantmonoclonalantibodytoCD52.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaYTH34.5-G2b(Campath-1G).
ThischimericrabbitantibodywasmadeusingthevariabledomainsequencesoftheoriginalRatIgG2bformat,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:RabbitIgG,kappa
CloneNumber:YTH34.5-G2b(Campath-1G)
UniProtAccessionNumberofTargetProtein:PublishedApplication(s):CytotoxicityAssay;
ELISA;IHC-Fr;IHC-P;invivo;FC;WB
PublishedSpeciesReactivity:Human;RhesusMonkey;CynomolgusMonkey
Immunogen:HumanperipheralmononuclearcellsenrichedforT-cells.
Specificity:HumanCD52antigen,alsoknownasCAMPATH-1.CD52isexpressedathighdensitybylymphocytes,monocytes,eosinophils,thymocytesandmacrophages.Itisexpressedbymostlymphoidderivedmalignancies,althoughexpressiononmyelomacellsisvariable.
AntibodyFirstPublishedin:HaleGetal.RemovalofTcellsfrombonemarrowfortransplantation:amonoclonalantilymphocyteantibodythatfixeshumancomplement.Blood.1983Oct;62(4):873-82.PMID:6349718
Noteonpublication:Describesthegenerationandcharacterizationofthisantibody,includingitsT-celldepletingfunction.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.