Description:RecombinantmonoclonalantibodytoGM-CSF.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromtheEBVtransformedhumanBcellcloneGCC21.ThisantibodywascreatedusingourproprietaryFcSilent™engineeredFcdomaincontainingkeypointmutationsthatabrogatebindingtoFcgammareceptors.
SpeciesandIsotype:HumanIgG1,FcSilent™,kappa
CloneNumber:GCC21
UniProtAccessionNumberofTargetProtein:PublishedApplication(s):NTRL;Biacore;
ELISAPublishedSpeciesReactivity:Human
Immunogen:AntibodygeneratedbysequencingofmemoryB-cellsobtainedfromhumanpatientssufferingfromchronicautoimmunepulmonaryalveolarproteinosis.
Specificity:ThisantibodybindstohumanGM-CSFatasitedistincttocloneGCA43.
ApplicationNotes:ThisantibodybindstohumanGM-CSFandhasneutralizingactivity.
AntibodyFirstPublishedin:Piccolietal.NeutralizationandclearanceofGM-CSFbyautoantibodiesinpulmonaryalveolarproteinosisNatCommun.2015Jun16;6:7375PMID:26077231
Noteonpublication:Describesthegenerationandcharacterizationofthisantibody.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.