Description:RecombinantmonoclonalantibodytoCD4.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaMT310.
SpeciesandIsotype:MouseIgG1,kappa
CloneNumber:MT310
UniProtAccessionNumberofTargetProtein:P01730
PublishedApplication(s):WB;IP;IF;IHC-P;FC
PublishedSpeciesReactivity:Human;RhesusMonkey;CynomolgusMonkey
Immunogen:Specificity:mt310bindstotheextracellulardomainD1ofCD4–thesamesiteastheHIV-1gp120-bindingsite
ApplicationNotes:mt310caninhibitgp120bindingtoCD4,whichblocksHIVinfectivityofCD4+Tlymphocytes,aswellasthebindingofMHCII,whichresultsintheblockofT-cellactivation,poss
IBLyle
ADIngtotheinductionofanergy.AntibodybindingtoCD4additionallycausestheinductionofGM-CSF,TNF-α(onlyafter20?h)andIL-10.
AntibodyFirstPublishedin:Herzogetal.Monoclonalanti-CD4inarthritis.Lancet.1987Dec19;2(8573):1461-2.PMID:2892019
Noteonpublication:Describestheuseofthisantibodyinimmunosuppression.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSonly.
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.