absoluteantibody/Ab00805-1.6 Anti-HIV-1 protease [F11.2.32]/Ab00805-1.6/ 100 µg,Absolute Antibody,,Absolute Antibody,absoluteantibody,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：absoluteantibody/Ab00805-1.6 Anti-HIV-1 protease [F11.2.32]/Ab00805-1.6/ 100 µg

产品编号：Ab00805-1.6

市场价：¥8512.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$425.60

品牌： Absolute Antibody

公司：Absolute Antibody

公司分类：

商品介绍

Description:RecombinantmonoclonalantibodytoHIV-1protease.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaF11.2.32.ThisisaFabfragmentwithahis-tag.

ThisreformattedmouseantibodywasmadeusingthevariabledomainsequencesoftheoriginalMouseIgG1format,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.

SpeciesandIsotype:MouseFabfragment,His-Tagged,kappa
CloneNumber:F11.2.32
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):neutralize;ELISA
PublishedSpeciesReactivity:HIV-1
Immunogen:F11.2.32waspreparedbygeneratingahybridomacelllineinwhichmyelomacellswerefusedwithsplenocytesderivedfromBALB/cmiceimmunizedwithHIV-1PRinthepresenceofFreund"sadjuvant.F11.2.32wasselectedforitsABIlitytobindtoHIV-1PRbyELISA.
Specificity:F11.2.32FabbindstoHIV-1PRwithadissociationconstantof5nM(determinedbySPRatpH5.2)atanepitopeconsistingofMSLPGRWKPKM(aa36-46).HIV-1PRisahomodimericapartateproteasethatspecificallycleavestheviralGagandGag/Polpolyproteinprecursor.Acorrelationhasbeenobservedbetweentheactivityoftheproteaseandthedegreeofinfectivity,andsothisproteinisamajorantiviraltarget.
ApplicationNotes:TheIgGandFabvariantsofF11.2.32arebothabletostronglyinhibitthecatalyticactivityofHIV-1PR(IC50~35nM).InhibitionoccursbydistortingthenativestructureoftheHIV-1PRatthebaseoftheflapregion,whichplaysanimportantroleinregulatingaccesstotheactivesite.ThisantibodyisalsoabletodetectHIV-1PRbyELISA.
AntibodyFirstPublishedin:
Lescaretal.Preliminarycrystallographicstudiesofananti-HIV-1proteaseantibodythatinhibitsenzymeactivityProteinSci. 1996May;5(5):966-8.PMID:8732768Noteonpublication:DescribesthegenerationofthemAbF11.2.32anditscrystallizationincomplexwithpeptidefragmentsofHIV-1PR.

ProductForm

Purification:PurifiedbyImmobilizedMetalAffinityChromatography
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.

Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.

品牌介绍

Absolute Antibody于2012年在英国剑桥成立，是由英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司，可以在两周内提供100mg级的工程化抗体，并且不含动物成分，批间差极小，消除因补体和Fc受体造成的背景，使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。目前提供国内的产品主要包括：

l 科研用生物仿制药抗体

l 嵌合单克隆抗体

l 用于体内实验的重组抗体

l 表位标签

l 重组非IgG同型对照

l 重组蛋白（Fc融合蛋白）

公司介绍

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