Description:RecombinantmonoclonalantibodytoInfluenzaAHA.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromtheEBVtransformedhumanBcellcloneHA.MadewithAntibodySequenceslicensedfromHumabsBiomedSA.MadewithAntibodySequenceslicensedfromHumabsBiomedSA.
SpeciesandIsotype:HumanIgG1,kappa
CloneNumber:HA
UniProtAccessionNumberofTargetProtein:AlternativeName(s)ofTarget:haemagglutinin;hemagglutinin
PublishedApplication(s):ELISAPublishedSpeciesReactivity:InfluenzaAVirus(severalsubtypes)
Immunogen:MadebyimmortalizingIgG-expressingBcellsfromindividualsfollowingvaccinationwithseasonalinfluenzavaccine,containingH1andH3influenzaVirussubtypes.
Specificity:ThisantibodyspecificallyrecognizestheconformationalepitopeinthestemregionofHAinwhichaminoacidsequencesarehighlyconservedinH1N1,H5N1,H6N1,andH9N2subtypesofInfluenzaAviruThisantibodyusestheVH1-69*01,D3-10*01,JH5*02,VL2D-29*02andJL4.ThisantibodydoesnotcrossreactwithHAinH2N2,H3N2andH7N7subtypeofInfluenzaAVirus.Thisantibodyhasnoeffectonhaemagglutination-inhibitionactivity.
AntibodyFirstPublishedin:Corti,D.etal.Heterosubtypicneutralizingantibodiesareproducedbyindividualsimmunizedwithaseasonalinfluenzavaccine.JClinInvest120,1663–1673(2010).PMID:20389023
Noteonpublication:DescribestheisolationandanalysisofapanelofhumanantibodiesfromvaccinatedindividualsanditsevaluationusingVirusneutralizationassays.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.