UniProt Accession Number of Target Protein: Q13984
Immunogen: Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion normally produced in gastrointestinal tissue during fetal development, but only at very low levels in adults.
Specificity: Recognises human carcinoembryonic antigen.
Application Notes: This antibody binds to carcinoembryonic antigen and was used in the diagnosis of mammary carcinomas.
Antibody first published in:Goldenberg DM, Wegener W.Studies of breast cancer imaging with radiolabeled antibodies to carcinoembryonic antigen.Acta Med AustricaPMID:9227788Note on publication:Describes the use of this a radiolabeled version of this antibody in breast cancer imaging.
Immunofluorescent staining of rat pancreas using anti-CEA antibody Ab00281 Formaldehyde-fixed rat pancreas slices were stained with Ab00281-10.0 at 5µg/ml and detected with a FITC-conjugated secondary antibody. Ab00281 shows cross-reactivity with rat.
Immunohistochemical staining of human endometrial cancer using anti-CEA antibody Ab00281 Formalin fixed human endometrial cancer slices werewere stained with a Ab00281-10.0 at 5µg/ml.
Absolute Antibody于2012年在英国剑桥成立,是由英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司,可以在两周内提供100mg级的工程化抗体,并且不含动物成分,批间差极小,消除因补体和Fc受体造成的背景,使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。目前提供国内的产品主要包括:
l 科研用生物仿制药抗体
l 嵌合单克隆抗体
l 用于体内实验的重组抗体
l 表位标签
l 重组非IgG同型对照
l 重组蛋白(Fc融合蛋白)