UniProt Accession Number of Target Protein: P30273
Alternative Name(s) of Target: FceRI; IgE receptorImmunogen: Recombinant human protein, N-terminus.
Specificity: This antibody binds to human Fc epsilon receptor, but does not compete with IgE binding.
Application Notes: IE7 binds to human FceRIa, but does not compete with IgE binding or binding of the antibody IB10 (Ab01396).
Antibody first published in:PMID:
Immunofluorescence staining of U937 cells using anti-Fc epsilon R antibody (Ab01397) IE7. Immunofluorescence analysis of paraformaldehyde fixed U937 cells immobilized on Shi-fix™ cover-slips and stained with the chimeric rabbit IgG version of IE7 (Ab01397-23.0) at 10 µg/ml followed by Alexa Fluor® 488 secondary antibody (2 µg/ml), showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom Ab01397-23.0, DAPI, merged channels and an isotype control. The isotype control was stained with anti-Fluorescein antibody (Ab00102-23.0) followed by Alexa Fluor® 488 secondary antibody.
Absolute Antibody于2012年在英国剑桥成立,是由英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司,可以在两周内提供100mg级的工程化抗体,并且不含动物成分,批间差极小,消除因补体和Fc受体造成的背景,使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。目前提供国内的产品主要包括:
l 科研用生物仿制药抗体
l 嵌合单克隆抗体
l 用于体内实验的重组抗体
l 表位标签
l 重组非IgG同型对照
l 重组蛋白(Fc融合蛋白)