absoluteantibody/Ab00103-10.3 Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)]/Ab00103-10.3/ 200 µg,Absolute Antibody,,Absolute Antibody,absoluteantibody,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：absoluteantibody/Ab00103-10.3 Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)]/Ab00103-10.3/ 200 µg

产品编号：Ab00103-10.3

市场价：¥5400.00

场地：美国(厂家直采)

产品分类：其它>其它试剂>临床研究>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$270.00

品牌： Absolute Antibody

公司：Absolute Antibody

公司分类：

商品介绍

Description:RecombinantmonoclonalantibodytoerbB-2(Her-2/neu).ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthetherapeuticantibody4D5-8(trastuzumab).ThisantibodywascreatedusingourproprietaryFcSilent™engineeredFcdomaincontainingkeypointmutationsthatabrogatebindingtoFcgammareceptors.

NOTFORTHERAPEUTICUSE-Thisisaresearch-gradebiosimilar.Thisisachimericantibodycreatedforimprovedcompatibilitywithexistingreagents,assaysandtechniques.

SpeciesandIsotype:HumanIgG1,FcSilent™,kappa
CloneNumber:4D5-8(trastuzumab)
UniProtAccessionNumberofTargetProtein:P04626
AlternativeName(s)ofTarget:Metastaticlymphnodegene19protein(MLN19);Proto-oncogeneNeu;Proto-oncogenec-ErbB-2;Tyrosinekinase-typecellsurfacereceptorHER2;p185erbB2;p185HER2
PublishedApplication(s):ELISA;FC;IHC
PublishedSpeciesReactivity:Human
Immunogen:A431cells(humanepidermoidcarcinoma)(over)expressingEGFR.
Specificity:OncogenicproteinHer-2/neu(erbB-2),amemberofthefamilyofepidermalgrowthfactor(EGF)receptors,overexpressedin30%ofinvasivebreastcancersand70%ofductalcarcinomatainsitu,inasmallpercentageofmelanomas,andinothermalignanciesoriginatingfromvariousorgans,includingovary,kidney,colon,andbladder.
ApplicationNotes:ThisantibodybindstoerbB-2/Her-2/neuhastherapeuticindicationsparticularlyinthetreatmentofbreastcancer(c.f.Herceptin).ItcanalsobeusedtodetectHER-2byflowcytometryorIHC(Glazyrin2007).
AntibodyFirstPublishedin:
CarterP,PrestaL,GormanCM,RidgwayJB,HennerD,WongWL,RowlandAM,KottsC,CarverME,ShepardHM.Humanizationofananti-p185HER2antibodyforhumancancertherapy.ProcNatlAcadSciUSA.1992May15;89(10):4285-9.PMID:1350088Noteonpublication:Describesthehumanisationoftheantibody(alsoknownasHerceptin),showsitrecognisedHER2inawidevarietyofimmuno-assays.

ProductForm

Purification:ProteinAaffinitypurified

Suppliedin:PBSonly.

StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.

Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.

品牌介绍

Absolute Antibody于2012年在英国剑桥成立，是由英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司，可以在两周内提供100mg级的工程化抗体，并且不含动物成分，批间差极小，消除因补体和Fc受体造成的背景，使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。目前提供国内的产品主要包括：

l 科研用生物仿制药抗体

l 嵌合单克隆抗体

l 用于体内实验的重组抗体

l 表位标签

l 重组非IgG同型对照

l 重组蛋白（Fc融合蛋白）

公司介绍

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