Description:RecombinantmonoclonalantibodytoEGFR.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthetherapeuticantibodyMatuzumab.
SpeciesandIsotype:HumanIgG1,kappa
CloneNumber:Matuzumab
UniProtAccessionNumberofTargetProtein:P00533
AlternativeName(s)ofTarget:EpidermalGrowthFactorReceptor
PublishedApplication(s):Block;FC;WB
PublishedSpeciesReactivity:Human
Immunogen:DomainIIIoftheextracellulardomainofhumanEGRF.
Specificity:BindstohumanEGFR.
ApplicationNotes:ThisantibodybindstohumanEGFRatasidedistinctfrmtheantigenbindingsite,preventingconformationalre-arrangementrequiredfordimerization,aprocessessentialforhigh-affinitiyligandbinding(Schmiedel2008).
AntibodyFirstPublishedin:Murthyetal.Bindingofanantago
NISTicmonoclonalantibodytoanintactandfragmentedEGF-receptorpolypeptide.ArchBiochemBiophys.1987Feb1;252(2):549-60.PMID:2434025
Noteonpublication:DescribesthegenerationoftheparentalmurineantibodymAb425againsthumanA431carcinomacellsanditsactiononhumanEGFR.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSonly.
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.