Description:RecombinantmonoclonalantibodytoMERS-CoVSpikeProtein.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridoma4c2.
ThischimericrabbitantibodywasmadeusingthevariabledomainsequencesoftheoriginalMouseIgG1format,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:RabbitIgG,kappa
CloneNumber:4c2
UniProtAccessionNumberofTargetProtein:PublishedApplication(s):NTRL;
ELISA;Crystallization
PublishedSpeciesReactivity:MERS-CoV
Immunogen:Recombinantspikereceptor-bindingdomainofMERS-CoVpreparedfrominsectHigh5cells.
Specificity:ThisantibodybindsMERS-CoVspikeproteinatanepitopeoverlappingwiththereceptor-bindingdomain(MERS-R
BD).
ApplicationNotes:ThisantibodybindstoMERS-RBDandblocksvirusentryinvitrowithhighefficacybybothsterichindranceandinterface-residuecompetition.
AntibodyFirstPublishedin:Lietal.AhumanizedneutralizingantibodyagainstMERS-CoVtargetingthereceptor-bindingdomainofthespikeproteinCellResearch25,1237-1249PMID:26391698
Noteonpublication:Describesthegenerationaswellasfunctionalandstructuralcharacterizationofthisantibody.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.