Description:RecombinantmonoclonalantibodytoEGFR.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaC225(Cetuximab).ThisisaFabfragmentwithahis-tag.
ThischimericmouseantibodywasmadeusingthevariabledomainsequencesoftheoriginalHumanIgG1format,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:MouseFabfragment,His-Tagged,kappa
CloneNumber:C225(Cetuximab)
UniProtAccessionNumberofTargetProtein:P00533
PublishedApplication(s):Block;FC
PublishedSpeciesReactivity:Human
Immunogen:Theepidermalgrowthfactorreceptoristhecell-surfacereceptorformembersoftheepidermalgrowthfactorfamily(EGF-family)ofextracellularproteinligands.
Specificity:RecogniseshumanEGFR.
AntibodyFirstPublishedin:PrewettMetal.The
BIOLOGiceffectsofC225,achimericmonoclonalantibodytotheEGFR,onhumanprostatecarcinoma.JImmunotherEmphasisTumorImmunolPMID:9041461
Noteonpublication:Describeseffectofantibodyonhumanprostatecancer.
ProductForm
Purification:PurifiedbyImmobilizedMetalAffinityChromatography
Suppliedin:PBSonly.
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.