absoluteantibody/Ab00948-10.3 Anti-Envelope protein DIII [2D73]/Ab00948-10.3/ 200 µg,Absolute Antibody,,Absolute Antibody,absoluteantibody,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：absoluteantibody/Ab00948-10.3 Anti-Envelope protein DIII [2D73]/Ab00948-10.3/ 200 µg

产品编号：Ab00948-10.3

市场价：¥6384.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$319.20

品牌： Absolute Antibody

公司：Absolute Antibody

公司分类：

商品介绍

Description:RecombinantmonoclonalantibodytoEnvelopeproteinDIII.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridoma2D73.ThisantibodywascreatedusingourproprietaryFcSilent™engineeredFcdomaincontainingkeypointmutationsthatabrogatebindingtoFcgammareceptors.

ThischimerichumanantibodywasmadeusingthevariabledomainsequencesoftheoriginalMouseIgG1format,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.

SpeciesandIsotype:HumanIgG1,FcSilent™,kappa
CloneNumber:2D73
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):ELISA;crystallisation
PublishedSpeciesReactivity:DENV
Immunogen:BALB/cmicewereimmunisedwithrecombinantly-producedenvelopeproteindomainIII(EDIII)fromDENV-3.SplenocyteswereobtainedfromimmunisedmiceandfusedwiththeNS-1myelomacelllinetogeneratehybridomas.
Specificity:2D73reactswithresidues309-319(DKEMAETQHGT)withindomainIIIoftheDENVenvelopeprotein,showncrystallographically(Lietal,unpublished).AlthoughraisedagainstDENV-3EDIII,2D72cross-reactswithEDIIIfromallfourDENVSEROtypes.2D73doesnotreactwithotherDENV-relatedflaviviruses,suchasWNV,YFVandJEV.
ApplicationNotes:2D73wasabletostronglyneutraliseDENVinfectioninaserotype-independentmanner,shownusingbothELISAsandELISPOT-basedassays(Lietal,2013).2D73hasalsobeenused,asaFabfragment,tocrystallisetheDENV-4EDIIIprotein(Lietal,unpublished).
AntibodyFirstPublishedin:
Lietal.DenguevirusenvelopedomainIIIimmunizationelicitspredominantlycross-reactive,poorlyneutralizingantibodieslocalizedtotheABloop:implicationsfordenguevaccinedesign.JGenVirol.2013Oct;94(Pt10):2191-201.PMID:23851440Noteonpublication:Describesthegenerationandcharacterisationof25cross-reactiveanti-DENVmAbs.

ProductForm

Purification:ProteinAaffinitypurified

Suppliedin:PBSwith0.02%Proclin300.

StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.

Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.

品牌介绍

Absolute Antibody于2012年在英国剑桥成立，是由英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司，可以在两周内提供100mg级的工程化抗体，并且不含动物成分，批间差极小，消除因补体和Fc受体造成的背景，使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。目前提供国内的产品主要包括：

l 科研用生物仿制药抗体

l 嵌合单克隆抗体

l 用于体内实验的重组抗体

l 表位标签

l 重组非IgG同型对照

l 重组蛋白（Fc融合蛋白）

公司介绍

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