Description:RecombinantmonoclonalantibodytoCD62L.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaMEL-14.
ThischimericmouseantibodywasmadeusingthevariabledomainsequencesoftheoriginalRatIgG2aformat,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:MouseIgG2a,kappa
CloneNumber:MEL-14
UniProtAccessionNumberofTargetProtein:PublishedApplication(s):Block;IP;FC;IHC
PublishedSpeciesReactivity:Mouse
Immunogen:C3H/ebmouseBlymphoma38C-13.
Specificity:ThisantibodybindstomouseCD62Lthemouseperipherallymphnodehomingreceptor,whichisalectin-likecellsurfaceproteinrapidlydown-regulateduponcellactivationwithphorbol12-myristate13-acetate.
ApplicationNotes:ThisantibodydetectsmouseCD62Landhasbeenreportedtoinhibittheinteractionofneutrophilswithendothelialcellsinvitroandinhibitthemigrationofneutrophilsfromthebloodintositesofacuteinflammationintheskin(Lewinsohnetal.1987).
AntibodyFirstPublishedin:Lewinsohn,Bargatze&ButcherLeukocyte-endothelialcellrecognition:evidenceofacommonmolecularmechanismsharedbyneutrophils,lymphocytes,andotherleukocytes.JImmunol.1987Jun15;138(12):4313-21.PMID:3584977
Noteonpublication:Describesthegenerationofthis
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.