Description:RecombinantmonoclonalantibodytoRSV.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaRSHZ19(Felvizumab).
SpeciesandIsotype:MouseIgG2a,kappa
CloneNumber:RSHZ19(Felvizumab)
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):functional;ELISA
PublishedSpeciesReactivity:RSV
Immunogen:ThisantibodywaspreparedbythehumanizationofanFprotein-specificmurineMAb,RSV19.Morespecifically,moleculartechniqueswereusedtoinsertthecomplementaritydeterminingregionsfrommurineRSV19intoahumanIgG1heavyandklightchain-variabledomainframework.
Specificity:Thisantibodyisspecificfortheconservedfusion(F)proteinofRSV.
ApplicationNotes:Thoughshowntobesafeandwell-tolerated(Everitt,1996)andprotectiveagainstRSVinfectioninBALB/cmiceandcottonrats(Wyde,1995),thisantibodydidnotdemonstrateefficacyinaPhase3study(Reichert,2008).Ininvitrostudies,palivizumab,anotherhumanizedMabspecificfortheFproteinofRSV,was4to5-foldmorepotentthanfelvizumabinneutralisingRSV(Scott,1999).
AntibodyFirstPublishedin:
Tempestetal.Reshapingahumanmonoclonalantibodytoinhibithumanrespiratorysyncytialvirusinfectioninvivo.Biotechnology(NY).1991Mar;9(3):266-71Noteonpublication:Describestheoriginalproductionofthehumanizedanti-RSVantibodyfrommurineRSV19.

ProductForm

Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.