Description:RecombinantmonoclonalantibodytoMERS-CoVSpikeProtein.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaD12.
SpeciesandIsotype:MouseIgG1,kappa
CloneNumber:D12
UniProtAccessionNumberofTargetProtein:PublishedApplication(s):NTRL;
ELISA;Crystallization;IF
PublishedSpeciesReactivity:MERS-CoV
Immunogen:MERS-CoV(England1strain)S1protein.
Specificity:ThisantibodybindstoMERS-CoVspikeproteinreceptorbindingdomainontheS1protein.Itisreportedtocross-reactswithMERS-CoVstrainsEngland1,Bishan1,England1-D509G,whilstbindingtoEngland1-S532P,W535RandE536Risimpaired.
ApplicationNotes:ThisantibodybindstoMERS-spikeproteinreceptorbindingdomain,andhasneutralizingeffectinaninvitromodelandwaselicitedbyavaccineconferringlong-lastinginvivoprotection.ThisantibodydoesnotworkbyWesternBlot.
AntibodyFirstPublishedin:Wangetal.EvaluationofcandidatevaccineapproachesforMERS-CoVNatCommun6,7712(2015)PMID:26218507
Noteonpublication:Describesthegenerationaswellasfunctionalandstructuralcharacterizationofthisantibody.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.