Description:RecombinantmonoclonalantibodytoJEVvirions(E/PrM).ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthephagedisplayantibodyTJE12B02.
Thisfull-length,chimericrabbitantibodywasmadeusingthevariabledomainsequencesoftheoriginalHumanscFvformat,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:RabbitIgG,kappa
CloneNumber:TJE12B02
UniProtAccessionNumberofTargetProtein:PublishedApplication(s):NTRL;
ELISA;IP
PublishedSpeciesReactivity:JapaneseEncephalitisVirus
Immunogen:Phagedisplaylibrarypapanned3timesonpurifiedJapaneseencephalitisvirus(JEV)virions(Nakayamastrain)
Specificity:ThisantibodybidstoJEVvirions.ItisunclearwhetherthisantibodybindstotheE-proteinortoPrMasanimmunocomplexcontainingbothisprecipitatedbythisantibody.
ApplicationNotes:ThisantibodybindstoJEVvirionsandimmunoprecipitatesacomplexccontainingEandPrMprotein.InaFabformat,itshowedneutralizingactivityinaninvitrosystemusingbabyhamsterkidney(BHK)-21cells.
AntibodyFirstPublishedin:Arakawaetal.ConstructionofhumanFab(gamma1/kappa)libraryandidentificationofhumanmonoclonalFabpossessingneutralizingpotencyagainstJapaneseencephalitisvirus.MicrobiolImmunol.2007;51(6):617-25.PMID:17579273
Noteonpublication:Describesthegenerationaswellasfunctionalandstructuralcharacterizationofthisantibody.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.