Description:RecombinantmonoclonalantibodytoBetv1.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromtheB-celllineBAB2.
ThisreformattedhumanantibodywasmadeusingthevariabledomainsequencesoftheoriginalHumanIgG4format,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:HumanIgG1,kappa
CloneNumber:BAB2
UniProtAccessionNumberofTargetProtein:P15494
AlternativeName(s)ofTarget:MajorAllergenfromBirchPollen;BETVIA
PublishedApplication(s):ELISA;activate;WB
PublishedSpeciesReactivity:Birch(Betulapendula)
Immunogen:Betv1,amajorallergenoftheEuropeanwhitebirch.
Specificity:ThisantibodybindstoBetv1.Itrecognisesaminoacids1-74ofrecombinantBetv1byWesternBlot,whilstshowingnobindingtoAA75-160.
ApplicationNotes:ThisantibodybindstoBetv1andappearstoenhancebindingofIgEaswellasBetv1-inducedimmediate-typeskinreactionsandthusrepresent"enhancingantibodies".
AntibodyFirstPublishedin:Eibensteineretal.ExpressionofahumanIgG4antibody,BAB2,withspecificityforthemajorBirchpollenallergen,Betv1inEscherichiacoli:recombinantBAB2Fabsenhancetheallergicreaction.IntArchAllergyImmunol.1999Feb-Apr;118(2-4):190-2.PMID:10224374
Noteonpublication:Describesthegenerationandcharacterizationofthisantibody.
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.