Description:RecombinantmonoclonalantibodytoSARS-CoVSglycoprotein.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromtheEBVtransformedhumanBcellcloneS227.MadewithAntibodySequenceslicensedfromHumabsBiomedSA.MadewithAntibodySequenceslicensedfromHumabsBiomedSA.
ThischimericrabbitantibodywasmadeusingthevariabledomainsequencesoftheoriginalhumanIgG1format,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:RabbitIgG,kappa
CloneNumber:S227
UniProtAccessionNumberofTargetProtein:PublishedApplication(s):ELISA;NTRL
PublishedSpeciesReactivity:SARSVirus
Immunogen:MadebyimmortalizingIgG-expressingBcellsfromrecoveredSARSpatients.
Specificity:SARS-CoV-neutralizinghmAbs,bindstoSARS-CoVSglycoprotein,inhibitingthebindingoftheglycoproteintohumanACE2.S227wastestedprophylacticallyat10and1mg/kgin12-month-olbBALB/cmiceinfectedwithaletaldoseofSARS-CoV(106PFU)Urbani,GZ02andHC/SZ/61/03.AllanimalstreatedwithS227recoveredonday5.
AntibodyFirstPublishedin:RockxB,CortiD,DonaldsonE,SheahanT,StadlerK,LanzavecchiaA,BaricR.Structuralbasisforpotentcross-neutralizinghumanmonoclonalantibodyprotectionagainstlethalhumanandzoonoticSevereAcuteRespiratorySyndromeCoronaViruschallenge.JVirol.2008Apr;82(7):3220-35.doi:10.1128/JVI.02377-07.Epub2008Jan16.PMID:18199635
ProductForm
Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals.