UniProt Accession Number of Target Protein: P49278 

Alternative Name(s) of Target: Mite group 2 allergen Der p 2; Allergen Der p II; DPXImmunogen: The antibody was generated by immunising mice with Der p 2.

Specificity: H10 binds a distinct epitope to clones H3 and H5.

Application Notes: The VH and VL sequences of H10 were used to generate a chimeric recombinant IgE antibody. The binding of chimericH10 to Der p 2 was confirmed using SPR, with a Kd value of 0.0358 nM. SPR also showed it binds distinct epitopes to clones H3 and H5.

Antibody first published in:Christensen et al.Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challengeJ Allergy Clin Immunol. 2008 Aug;122(2):298-304.PMID:18572230Note on publication:Descibes the original production of the antibody and its characterisation through SPR.